There is no accumulation of ertapenem following multiple iv or im 1 g daily doses in healthy adults. Administration of ertapenem 1 gram iv push over 5 minutes was. Ertapenem drug monograph pediatric care online aap. Intravenous compatibility chart free html5 flip book. Invanz 1g powder for concentrate for solution for infusion. Although ertapenem can be used for infections caused by susceptible microorganisms that are resistant to all other antibiotics, it has specific approval to be used empirically in acute pelvic infections and complicated intraabdominal infections. Pharmacokinetics and optimal dose of ertapenem in hemodialysis patients the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Intravenous admixtures preparation and infusion guidelines. An alternative to the iv ertapenem administration is needed because of poor venous access and behavioural abnormalities commonly present in infected elderly population. Consumer information about the medication ertapenem injection invanz, includes side effects, drug interactions, recommended dosages, and storage information.
Stability of ertapenem in an elastomeric infusion device. Phipps stephen d, peacock gina f, smith douglas l issue. Find patient medical information for ertapenem intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Find information about common, infrequent and rare side effects of ertapenem intravenous. Stability of ertapenem 100 mgml in manufacturers glass. Ertapenem injection route description and brand names. Solutions reconstituted for im administration should not be given iv. Ertapenem is active against many resistant enteric gram negative. Ertapenem was reconstituted with sterile water for injection and then diluted with various commercial i. Mayjun 2011 volume 15, number 3 view all articles in issue. Stay informed of new and updated iv drug compatibility and stability.
Ertapenem is injected into a muscle or into a vein through an iv. This medication is known as a carbapenemtype antibiotic. Stability and compatibility of reconstituted ertapenem with commonly. Invanz ertapenem for injection is a type of antibiotic used to treat severe infections of the skin, lungs, stomach, pelvis, and urinary tract. Listing a study does not mean it has been evaluated by the u. Ertapenem je organsko jedinjenje, koje sadrzi 22 atoma ugljenika i ima molekulsku masu od 475,515 da. Intravenous iv preparation and infusion guidelines globalrph. Ertapenem is a bacterial cell wall biosynthesis inhibitor with activity against a wide range of gramnegative and grampositive bacteria and resistance to a broad and extended spectrum of. It is also used to prevent infection in people having certain types of surgery. It works by killing bacteria or preventing their growth. Ertapenem sodium reference guide for safe and effective use from the american. This reference contains standard dilutions including iv admixture drug concentration, infusion volumes, and infusion rates. E5280, 2017, 352 pages get the support you need to safely extend dating of parenteral drugs beyond the usual 24hour limitminimizing waste, lowering medication costs, and enabling optimal patient administration schedules at alternate infusion sites.
Agents with antipseudomonal activity, including doripenem, imipenem, and meropenem are not recommended in this population. Minor hydrolysis of betalactam ring, cyp not involved. Provides a summary of interactions with vitamins, herbs, and food. Dailymed invanz ertapenem sodium injection, powder. Stability and compatibility of reconstituted ertapenem. The king guide to parenteral admixtures is designed to help practitioners decide which alternative administration strategy is best. Cvvhd removes solutes including drugs via diffusion. The following is the list of drugs found in the king guide to parenteral admixtures looseleaf, and internet editions. Of the 80% recovered in urine, approximately 38% is.
Read more about the prescription drug ertapenem injection. Ertapenem for prophylaxis and treatment of infections in children. Ertapenem sodium reference guide for safe and effective use from the american society of healthsystem pharmacists ahfs di. Midazolam versed yes midazolam versed yes midazolam versed. If ertapenem is given 6 hours or more prior to hemodialysis, no supplemental dosing is required. Infusion vials 500 mg and 1g may be directly constituted with a compatible infusion. Ertapenem is not active against pseudomonas aeruginosa. To evaluate the stability of ertapenem after reconstitution with 0. For the patients with creatinine clearance crcl equal to or greater than 30 mlmin, no adjustment is necessary.
Ertapenem sodium dosage and administration administration. Reconstitute 1 gram vial with 10 ml of water for injection, 0. Side effects of invanz ertapenem injection, warnings, uses. Prophylactic administration of ertapenem as a single 1g iv dose has been shown to reduce sepsis after prostate biopsy. Invanz ertapenem dosing, indications, interactions. This medicine will not work for colds, flu, or other virus infections. The carbapenem ertapenem is one of several firstline agents recommended by the infectious disease society of america for the empiric treatment of communityacquired intraabdominal infections of mildtomoderate severity. Do not use solvents or infusion fluids containing dextrose for reconstitution or administration of ertapenem. Switching to iv push, using solutions other than saline, using large volume solutions, or using syringe infusion pumps, may change the stability and compatibility characteristics of the medication to be. Prophylactic administration of ertapenem as a single 1g iv dose has been.
If ertapenem is given within 6 hours of hemodialysis, a supplementary dose of 150 mg is recommended following the hemodialysis session. It will not work for colds, flu, or other viral infections. Ertapenem exhibits nonlinear pharmacokinetics due to concentrationdependent plasma protein binding at the proposed therapeutic dose see clinical pharmacology 12. Highlights of prescribing information these highlights do not include all the information needed to use. Dilute with compatible fluid to a concentration of 20mgml or less. Pharmacokinetics of ertapenem in patients aged over 75. Stability and compatibility of reconstituted ertapenem with commonly used i. It showed clinical activity in the treatment of obstetric and gynecological infections, skin and soft tissue infections, communityacquired pneumonia, urinary tract infections, and in intra.
Detailed listing of the iv drug compatibility and stability updates applied to the king guide to parenteral admixtures over the last 12 years. Invanz ertapenem for injection for intravenous iv or intramuscular im use. Ertapenem is used to treat severe infections of the skin, lungs, stomach, pelvis, and urinary tract. Do not selfinject this medicine if you do not fully understand how to give the. The stability of ertapenem sodium in various commonly used i. Renal dose adjustment guidelines for antimicrobials crrt. Further dilute vials with compatible iv solution i. Ertapenem is used to prevent and treat a wide variety of bacterial infections. Ertapenem is currently sc administrated in geriatric departments if no other option is available.
Trissel, fashp, 2010, american society of healthsystem pharmacists. Invanz 1g powder for concentrate for solution for infusion summary of product characteristics. Pharmacokinetics of ertapenem in patients aged over 75 phacinerta. Ertapenem is used alone or in combination with other antibiotics to treat infections caused by bacteria in many different parts of the body. For solution and drug compatibility information, see compatibility under stability. You can publish your book online for free in a few minutes. Ertapenem erythromycin gluceptate erythromycin lactobionate esmolol hydrochloride. Ertapenem injection invanz side effects, medical uses. Intravenous compatibility chart acyclovir acyclovir. When a patient is initiated on crrt, antimicrobial therapy often requires adjustment to ensure adequate drug concentrations are achieved.
It is used to treat certain kinds of bacterial infections. Ertapenem binds to penicillin binding proteins pbps located on the bacterial cell wall, in particular pbps 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Ertapenem is a powder medicine that must be mixed with a liquid diluent before using it. Invanz ertapenem dose, indications, adverse effects. Ertapenem is an intravenous antibiotic that is dosed once daily and is utilized in the home infusion setting for parenteral antibiotic therapy thepurpose of this study was to evaluate the. Common and rare side effects for ertapenem intravenous. Following the administration of 1 g iv radiolabeled ertapenem to healthy young adults, approximately 80% is recovered in urine and 10% in feces. Ertapenem may also be used for purposes not listed in this medication guide. Invanz is also used to prevent infection in people having certain types of surgery. The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Ertapenem side effects, dosage, interactions drugs. Ertapenem is a 1betamethyl carbapenem and broadspectrum betalactam antibiotic with bactericidal property. But in my book, and on the big compatability chart that is hanging in the med room, it doesnt list common fluids with additives.
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